The first recorded instance of a tomato-based sauce in Italian cuisine wasn’t until the 1790s (in the Italian cookbook L’Apicio moderno, by Roman chef Francesco Leonardi). Tomatoes were a product of the New World and only appeared in Italy after importation.

While small doses of caffeine (such as drinking a single cup of coffee) can increase alertness and have other positive effects, doses in excess of 200mg (such as drinking multiple cups of coffee at a time or taking caffeine pills) can cause increased anxiety along with nervousness, jitteriness, and an upset stomach.