If you use Microsoft Outlook as the center for all your communications, you might be interested in integrating Twitter directly into Outlook so you never have to leave the comfort of your inbox to read about the daily minutia of your twitter friends.
The OutTwit add-on for Outlook allows you to both send and receive messages directly, and has now become my preferred Twitter client.
Sending messages is about as simple as it gets… just type and hit the enter key.
All of your messages will show up in your Inbox by default, but you can (and should) change that easily in the preferences.
In the preferences you can add your user information, but more importantly you should create a separate folder to store the messages in because they can really overflow your inbox quickly.
You might notice the option to use tinyurl to shorten the URLs, also very useful.
I really don’t use Twitter very much since I’m trying to be productive these days, but if you want to follow me have at it.