A shortlist from experience is;
Inability to come out of hibernation, sleep ( especially after an M$ update ) Excessive reboots required!
Open docs lost because of this after reboot.
'Sleep is a power-saving state that allows a computer to quickly resume full-power operation (typically within several seconds) when you want to start working again. Putting your computer into the sleep state is like pausing a DVD player—the computer immediately stops what it’s doing and is ready to start again when you want to resume working.
Hibernation is a power-saving state designed primarily for laptops. While sleep puts your work and settings in memory and draws a small amount of power, hibernation puts your open documents and programs on your hard disk, and then turns off your computer. Of all the power-saving states in Windows, hibernation uses the least amount of power. On a laptop, use hibernation when you know that you won't use your laptop for an extended period and won't have an opportunity to charge the battery during that time.
Hybrid sleep is designed primarily for desktop computers. Hybrid sleep is a combination of sleep and hibernate—it puts any open documents and programs in memory and on your hard disk, and then puts your computer into a low-power state so that you can quickly resume your work. That way, if a power failure occurs, Windows can restore your work from your hard disk. When hybrid sleep is turned on, putting your computer into sleep automatically puts your computer into hybrid sleep. Hybrid sleep is typically turned on by default on desktop computers.'
An article to read;
Screensavers are not required on a modern monitor, they were there to protect the old CRT monitors. However, SS are still written, stay resident ( in mode set ) and some are written with much malevolent code.
With the proverbial 33 foot bargepole, disable all the above options