Does the touchpad work?
Can you plug another type of device (ie ext. drive) into that usb port (to check if it is a mouse or port problem)

Have a look in Control Panel > Device Manager. Expand the "Universal Serial Bus Controllers" and then right click on each one in turn, selecting "Properties" each time. Anything unusual there?

Does the mouse work in another port?

With the mouse plugged in, goto Device Manager. Right click on "Mice and other Pointing Devices" and select "Scan for hardware changes"

Did it stop working just after you installed Vista Updates?

Perhaps it missed you, and is now sulking?

I can offer no more at the moment, sorry. But I will keep looking/thinking. Maybe someone else will come up with something!

There is a little button on the USB dongle (receiver) and also on the bottom of the mouse. Press both those buttons at the same time for about 20 seconds. That will sync the mouse with the dongle and it should work then.

Lighthouse, ya, you're right. Missed that part. Maybe there is a problem with the power setting of the hub. Have to do some research to find that part - don't remember right now. We discussed that when I wanted to cut the power on the USB ports. But I forgot the details. Have to proceed to lunch now. If you have a minute, have a look.
http://www.howtogeek.com/forum.....replies=34

no suggestions whs???!?
it's not that simple
first of all..there is no button on the usb reciever for my mouse, it looks just like a little flash drive type of thing, no buttons though, there is one on my mouse, yes, but i've only tried that a billion times. I think it has to be something with my usb ports, because i have now tried the mouse on my desktop computer, and it worked just fine, but neither the cordless nor corded mouse will work on my laptop. To make matters worse, i was foolisly trying to fix this problem and did a system restore back to a few days ago, now my touchpad settings are kapput and I can't seem to get back to change them, it always says (not respondng) and then i get a message about some windows shell dll can not be accessed or something like that.. I am at a loss without my mouse.. someone.. anyone.. you have to know something?!?